Recombinant human CCL23 1-99 is expressed in E. coli, refolded and purified to yield the mature form of protein that is secreted from cells after cleavage of the signal peptide to yield a 99 residue polypeptide. Human CCL23, also designated CK-beta-8, Macrophage inflammatory protein 3 (MIP-3), Myeloid progenitor inhibitory factor 1 (MPIF-1) and small-inducible cytokine A23, attracts monocytes, resting T-lymphocytes, and neutrophils through activation of the G protein-coupled receptor CCR1. Alternative splicing results in a second isoform 116 amino acids in length. Additional proteolytic processing at the N terminus (e.g. CCL23 25-99) reportedly yields a more potent form of the chemokine.
Amino Acid Sequence:
|Molecular Weight:||11335.21 Daltons|
|Purity:||Assessed by HPLC, Mass Spectrometry, and NMR.|
|Source:||Human protein expressed in E. coli|
|Physical Form:||Lyophilized powder|
|Solubility:||Freely Soluble in Water|
|Storage Conditions:||Store at -20o C|
Additional comments or descriptive information:
J Biol Chem. 2001 Feb 16;276(7):4909-16. http://www.jbc.org/content/276/7/4909.long
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Recombinant Human CCL23 (1-99)
- Product Code: PFP057
- Availability: In Stock