Recombinant human CXCL9 is expressed in E. coli, refolded and purified to yield the mature form of protein that is secreted from cells after cleavage of the signal peptide. Human CXCL9 is a 103 amino acid protein expressed by IFN-gamma macrophages and glial cells.
T-cells expressing the G protein-coupled receptor, CXCR3, will migrate and release intracellular calcium in response to CXCL9 stimulation.
Amino Acid Sequence:
|Molecular Weight:||11720.81 Daltons|
|Purity:||> 98% by SDS-PAGE, HPLC, MALDI-MS and NMR.|
|Source:||Human protein expressed in E. coli|
|Physical Form:||Lyophilized powder|
|Solubility:||Freely Soluble in Water|
|Storage Conditions:||Store at -20o C|
Additional comments or descriptive information:
Weng, Y., Siciliano, S. J., Waldburger, K. E., Sirotina-Meisher, A., Staruch, M. J., Daugherty, B. L., . . . DeMartino, J. A. (1998). Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem, 273(29), 18288-18291.
Loetscher, M., Gerber, B., Loetscher, P., Jones, S. A., Piali, L., Clark-Lewis, I., . . . Moser, B. (1996). Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med, 184(3), 963-969
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Recombinant Human CXCL9
- Product Code: CXCL9
- Availability: In Stock