Recombinant human CXCL1 is expressed in E. coli, refolded and purified to yield the mature protein that is secreted from cells after cleavage of the signal peptide. Human CXCL1 is a 73 amino acid, ELR+ chemokine that belongs to the GRO isoform subset which activate the G protein-coupled receptor CXCR2. TNF-stimulated epithelial cells strongly express CXCL1 in addition to the constitutive expression by macrophages. CXCL1 is a potent chemoattractant for neutrophils and an activator of basophils.
Amino Acid Sequence:
|Molecular Weight:||7861.2 Daltons|
|Purity:||Assessed by HPLC, Mass Spectrometry, and NMR|
|Source:||Human protein expressed in E. coli|
|Physical Form:||Lyophilized powder|
|Solubility:||Freely Soluble in Water|
|Storage Conditions:||Store at -20o C|
Additional comments or descriptive information:
Moser, B., Clark-Lewis, I., Zwahlen, R., & Baggiolini, M. (1990). Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med, 171(5), 1797-1802.
Becker, S., Quay, J., Koren, H. S., & Haskill, J. S. (1994). Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol, 266(3 Pt 1), L278-286.
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Recombinant Human CXCL1
- Product Code: PFP029
- Availability: In Stock