Recombinant human CXCL13 protein is expressed in E. coli, refolded and purified as the native form of the mature chemokine to yield a 87 residue polypeptide. Human CXCL13, also known as beta cell attracting chemokine (BCA-1) or beta cell ligand (BCL), is the ligand for the G protein coupled receptor CXCR5. CXCL13 is strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes over T cells and macrophages.
Amino Acid Sequence:
|Molecular Weight:||10313.34 Daltons|
|Purity:||> 98% by SDS-PAGE, HPLC, MALDI-MS and NMR.|
|Source:||Human protein expressed in E. coli|
|Physical Form:||Lyophilized powder|
|Solubility:||Freely Soluble in Water|
|Storage Conditions:||Store at -20o C|
Additional comments or descriptive information:
Gunn, M. D., Ngo, V. N., Ansel, K. M., Ekland, E. H., Cyster, J. G., & Williams, L. T. (1998). A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature, 391(6669), 799-803. Retrieved from http://dx.doi.org/10.1038/35876
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Recombinant Human CXCL13 (1-87)
- Product Code: PFP019
- Availability: In Stock