Recombinant human CXCL10 is expressed in E. coli, refolded and purified to yield the mature form of protein that is secreted from cells after cleavage of the signal peptide. Human CXCL10 is a 77 amino acid protein that is expressed by monocytes, endothelial cells and fibroblasts. It is a potent T-cell chemoattractant through binding and activation of the G protein-coupled receptor CXCR3
Amino Acid Sequence:
|Molecular Weight:||8642.3 Daltons|
|Purity:||> 98% by SDS-PAGE, HPLC, MALDI-MS and NMR.|
|Source:||Human protein expressed in E. coli|
|Physical Form:||Lyophilized powder|
|Solubility:||Freely Soluble in Water|
|Storage Conditions:||Store at -20o C|
Additional comments or descriptive information:
Weng, Y., Siciliano, S. J., Waldburger, K. E., Sirotina-Meisher, A., Staruch, M. J., Daugherty, B. L., . . . DeMartino, J. A. (1998). Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem, 273(29), 18288-18291.
Luster, A. D., Unkeless, J. C., & Ravetch, J. V. (1985). Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature, 315(6021), 672-676.
Dufour, J. H., Dziejman, M., Liu, M. T., Leung, J. H., Lane, T. E., & Luster, A. D. (2002). IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol, 168(7), 3195-3204.
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Recombinant Human CXCL10
- Product Code: PFP017
- Availability: In Stock