Recombinant human CXCL4 is expressed in E. coli, refolded and purified to yield the mature form of protein that is secreted from cells after cleavage of the signal peptide. Human CXCL4, additionally known as Platelet-factor 4, is a 70 amino acid protein that is released by activated platelets to promote coagulation. CXCL4 binds to the G protein-coupled receptor CXCR3-B, found in kidney, heart and liver tissue, but a canonical signaling receptor is still unknown. CXCL4 readily binds to heparin-like molecules and glycoproteins and is a regulator of endothelial and homeopathic stem cell proliferation.
Amino Acid Sequence:
|Molecular Weight:||7765.18 Daltons|
|Purity:||> 98% by SDS-PAGE, HPLC, MALDI-MS and NMR.|
|Source:||Human protein expressed in E. coli|
|Physical Form:||Lyophilized powder|
|Solubility:||Freely Soluble in Water|
|Storage Conditions:||Store at -20o C|
Additional comments or descriptive information:
Lasagni, L., Francalanci, M., Annunziato, F., Lazzeri, E., Giannini, S., Cosmi, L., . . . Romagnani, P. (2003). An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med, 197(11), 1537-1549. doi:10.1084/jem.20021897
Amelot, A. A., Tagzirt, M., Ducouret, G., Kuen, R. L., & Le Bonniec, B. F. (2007). Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin. J Biol Chem, 282(1), 710-720. doi:10.1074/jbc.M606650200
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Recombinant Human CXCL4
- Product Code: PFP014
- Availability: In Stock