CCL21 protein is expressed in E. coli, processed, refolded and purified to yield the native, secreted form of the mature chemokine.
CCL21 is a human chemokine that recruits normal immune cells and metastasizing tumor cells to lymph nodes through activation of the G protein-coupled receptor CCR7. CCL21 contains 6 conserved cysteines, in contrast to the 4 that are more typical of CC chemokines. CCL21 induces chemotactic migration of thymocytes and activated T-cells, but not B-cells, macrophages, or neutrophils.
Amino Acid Sequence:
|Molecular Weight:||12247.2 Da|
|Purity:||> 98% by SDS-PAGE, HPLC, MALDI-MS and NMR.|
|Source:||Human protein expressed in E. coli|
|Physical Form:||Lyophilized powder|
|Solubility:||Freely Soluble in Water|
|Storage Conditions:||Store at -20o C|
Additional comments or descriptive information:
Solution Structure of CCL21 and Identification of a Putative CCR7 Binding Site
Melissa Love, Jamie L. Sandberg, Joshua J. Ziarek, Kyle P. Gerarden, Renee R. Rode, Davin R. Jensen, Darrell R. McCaslin, Francis C. Peterson, and Christopher T. Veldkamp Biochemistry 2012 51 (3), 733-735
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Recombinant Human CCL21
- Product Code: PFP010
- Availability: In Stock