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  • Recombinant Human CXCL12/SDF-1 beta

CXCL12 protein is expressed in E. coli, processed, refolded and purified to yield the native, secreted form of the mature chemokine.

CXCL12 is a ligand for the G protein coupled receptor CXCR4, and induces chemotactic migration in a wide range of CXCR4-expressing cells. CXCL12 protein is expressed in E. coli as an N-terminal fusion with Sumo before it is refolded and cleaved via ULP1 protease to yield the native, secreted form of the mature chemokine.

Amino Acid Sequence:

KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRFKM

Molecular Weight:  8522.1 Da
Fusion Tag: N/A
Special Characteristic(s): N/A
Purity: > 98% by SDS-PAGE, HPLC, MALDI-MS and NMR.
Source: Human protein expressed in E. coli
Physical Form: Lyophilized powder
Solubility: Freely Soluble in Water
Storage Conditions: Store at -20o C

Additional comments or descriptive information:

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References:

  1. Oberlin E et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1 Nature. 1996 382 833-5.
  2. Bleul CC, et al The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 1996 382 829-33.

If you publish research with this product, please let us know so we can cite your paper.

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Recombinant Human CXCL12/SDF-1 beta

  • Product Code: CXCL12 beta
  • Availability: In Stock
  • $0.00

  • Ex Tax: $0.00

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Tags: Cytokine, Chemokine, CXCL12, SDF-1 beta