CXCL12 protein is expressed in E. coli, processed, refolded and purified to yield the native, secreted form of the mature chemokine.
CXCL12 is a ligand for the G protein-coupled receptor CXCR4 and induces chemotactic migration in a wide range of CXCR4-expressing cells. CXCL12 protein is expressed in E. coli as an N-terminal fusion with Sumo before it is refolded and cleaved via ULP1 protease to yield the native, secreted form of the mature chemokine.
Amino Acid Sequence:
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRFKM
|Molecular Weight:||8522.1 Da|
|Purity:||Assessed by HPLC, Mass Spectrometry, and NMR|
|Source:||Human protein expressed in E. coli|
|Physical Form:||Lyophilized powder|
|Solubility:||Freely Soluble in Water|
|Storage Conditions:||Store at -20o C|
Additional comments or descriptive information:
- Oberlin E et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1 Nature. 1996 382 833-5.
- Bleul CC, et al The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 1996 382 829-33.
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Recombinant Human CXCL12/SDF-1 beta
- Product Code: PFP002
- Availability: In Stock