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  • Recombinant Human XCL1 /Lymphotactin (Ltn)

XCL1 protein is expressed in E. coli, processed, refolded and purified to yield the native, secreted form of the mature chemokine.

XCL1 is a ligand for the G protein coupled receptor XCR1 with and EC50 ~ 50 nM. It has been shown the WT XCL1 is able to interconvert between two distinct conformations under physiological conditions. In one conformation, XCL1 exists as a monomer and is able to bind to its receptor. In the other conformation, XCL1 exists as a dimer and loses affinity for XCR1 (1,2)

Amino Acid Sequence:

VGSEVSDKRT CVSLTTQRLP VSRIKTYTIT EGSLRAVIFI TKRGLKVCAD PQATWVRDVV RSMDRKSNTR NNMIQTKPTG TQQSTNTAVT LTG

Molecular Weight:  10269.7 Daltons 
Fusion Tag: N/A
Special Characteristic(s): N/A
Purity: > 98% by SDS-PAGE, HPLC, MALDI-MS and NMR.
Source: Human protein expressed in E. coli
Physical Form: Lyophilized powder
Solubility: Freely Soluble in Water
Storage Conditions: Store at -20o C
   

Additional comments or descriptive information:

 

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References:

  1. Tunistra, R.L., Peterson, F.C., Elgin, E.S., Pelzek, A.J., & Volkman, B.F.  An Engineered Second Disulfide Bond Restricts Lymphotactin/XCL1 to a Chemokine-­‐like Conformation with XCR1 Agonist Activity. Biochemistry 46, 2564-­‐2573 (2007).
  2. Tunistra, R.L.,  Peterson, F.C., Kutlesa, S., Elgin, E.S., Kron, M.A., & Volkman, B.F. Interconversion between two unrelated protein folds  in the lymphotactin native state.  PNAS 105, 5057-­‐5062 (2008).

If you publish research with this product, please let us know so we can cite your paper.

Recombinant Human XCL1 /Lymphotactin (Ltn)

  • Product Code: PFP005
  • Availability: In Stock
  • $0.00


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Tags: Cytokine, Chemokine, lymphotactin, SCYC1, LTN, LPTN, ATAC, SCM-1, XCL1